THE BASIC PRINCIPLES OF LACHGAS

The final proposed mechanism of RBC vasodilation in the existence of nitrite is definitely the reduction of nitrite to NO by Hb. Brooks first examined the nitrite Hb conversation in 1937 and this function was later on extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to variety metHb and NO (Brooks, 1